Accession Number : ADB248366


Title :   Bone Factors Regulating the Osteotropism of Metastatic Breast Cancer


Descriptive Note : Annual rept. 22 Sep 1997-21 Sep 1998,


Corporate Author : CHILDREN'S HOSPITAL CORP BOSTON MA


Personal Author(s) : Hauschka, Peter V


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/b248366.pdf


Report Date : Oct 1998


Pagination or Media Count : 24


Abstract : This project seeks to identify the critical molecular interactions and cellular processes responsible for the preferential establishment of breast cancer metastases in the human skeleton. We are testing the hypothesis that malignant breast adenocarcinoma cells subvert the cooperative paracrine interactions between normal bone cells, endothelial cells, and the extracellular matrix in order to establish metastatic foci. We have developed strong preliminary data showing mimicry of the osteoblast phenotype by invasive breast adenocarcinoma cells; this mimicry includes a pattern of gene expression which may explain the osteotropism (homing and metastatic growth in bone) of breast cancer. In model human cell lines, and sublines recovered from bone metastases in nude mice, the inappropriate expression of the bone specific transcription factor CBFA1 appears to correlate with the degree of malignancy, and this probably drives the osteoblast mimicry; normal breast tissue does not express CBFA1.


Descriptors :   *MEDICAL RESEARCH , *METASTASIS , *BREAST CANCER , TISSUES(BIOLOGY) , GENES , MOLECULE MOLECULE INTERACTIONS , CELLS(BIOLOGY) , BONES , ENDOTHELIUM , GROWTH(PHYSIOLOGY) , CYTOLOGY


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE