Accession Number : ADB205250


Title :   Production of Polyclonal Antibodies in Rabbits


Descriptive Note : Final rept. 1 Mar 1993-31 Aug 1995


Corporate Author : BIOTEK INC WOBURN MA


Personal Author(s) : Nuwayser, Elis S


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/b205250.pdf


Report Date : Oct 1995


Pagination or Media Count : 103


Abstract : The project was directed to the Medical Chemical Defense Research Program. Under the broad mission of providing medical countermeasures to chemical warfare agents, the work was relevant to develop the use of exogenous cholinesterase enzymes as a pretreatment to protect against organophosphorous chemical agents. The threat of deadly exposure to chemical agents is still significant for American military personnel and the American public. The recent use of sarin by Japanese extremists in subway sta- tions in Japan is witness to that. Amongst the most lethal chemical agents are organophosphorous (OP) compounds such as soman, sarin, and tabun. Poisoning from these agents can lead to rapid and severe dysfunction and even death from respiratory failure within five minutes (Gilman, et al., 1990).


Descriptors :   *CHEMICAL WARFARE AGENTS , *CHOLINESTERASE , *COUNTERMEASURES , *MEDICINE , *MILITARY MEDICINE , *MONOCLONAL ANTIBODIES , DEATH , DYSFUNCTION , ENZYMES , EXPOSURE(GENERAL) , FAILURE , GA AGENT , GB AGENT , GD AGENT , JAPAN , LETHAL AGENTS , MILITARY PERSONNEL , MISSIONS , ORGANIC PHOSPHORUS COMPOUNDS , ORGANOPHOSPHATES , POISONING , RABBITS , RESPIRATORY SYSTEM


Subject Categories : Medicine and Medical Research
      Biochemistry
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE