Accession Number : ADB013303


Title :   The use of Aotus Trivirgatus and Macaca Mulatta as Tools for Studies on Prevention and Therapy of Infections with Plasmodium Falciparum and Plasmodium Vivax


Descriptive Note : Annual progress rept. 1 May 1975-30 Apr 1976


Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL KETTERING-MEYER LAB


Personal Author(s) : Schmidt, L H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b013303.pdf


Report Date : 13 Aug 1976


Pagination or Media Count : 373


Abstract : As in previous years, the activities of this Project were focused on development of: (a) agents fully effective against infections with blood schizonts of multidrug-resistant strains of Plasmodium falciparum and P. vivax in the owl monkey; and (b) compounds more active than primaquine against the tissue schizonts of P. cynomolgi in the rhesus monkey, and better tolerated. Only three new agents were examined for blood schizonticidal activity. One of these, WR-226, 253, a quinolinemethanol, exhibited activity equal to or surpassing that of WR-142, 490 (Mefloquine), the most effective blood schizonticide available heretofore. Forty-five newly prepared compounds, including thirty-eight 8-aminoquinolines, were examined for tissue schizonticidal activity in the rhesus monkey-P. cynomolgi model.


Descriptors :   *ANTIMALARIALS , *MALARIA


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE