Accession Number : ADA627593


Title :   Fatal acute Chagas Disease in a Chimpanzee


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Bommineni, Yugendar R ; Dick, Jr, Edward J ; Estep, J S ; Van de Berg, John L ; Hubbard, Gene B


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA627593


Report Date : Aug 2009


Pagination or Media Count : 10


Abstract : Background Chagas disease (CD) or American trypanosomiasis is caused by a hemoflagellate protozoan, Trypanosoma cruzi (TC). This organism has been isolated from more than 100 mammalian species and several insect vectors demonstrating a wide host distribution and low host specificity. Methods A 23 year old male chimpanzee died acutely and a complete necropsy was performed to evaluate gross and microscopic pathologic changes. After observation of trypanosomal amastigotes in the myocardium, PCR and immunohistochemistry was employed to confirm the diagnosis of TC. Results Gross findings were consistent with mild congestive heart failure. Microscopic findings included multifocal myocardial necrosis associated with severe lymphocytic to mixed inflammatory infiltrates, edema, and mild chronic interstitial fibrosis. Multifocal intracytoplasmic amastigotes morphologically consistent with TC were observed in cardiac myofibers. TC was confirmed by PCR and immunohistochemistry. Conclusion We report, to the best of our knowledge, the first fatal spontaneous case of TC infection in a chimpanzee.


Descriptors :   *CHAGAS DISEASE , *CHIMPANZEES , *TRYPANOSOMA CRUZI , AUTOPSY , CLINICAL MEDICINE , CONGESTIVE HEART FAILURE , DIAGNOSIS(MEDICINE) , EDEMA , FIBROSIS , HEART , HISTOCHEMISTRY , HOSTS(BIOLOGY) , IMMUNOCHEMISTRY , INFECTIOUS DISEASES , INFLAMMATION , INTERSTITIAL , LYMPHOCYTES , MASTIGOTES , MYOCARDIUM , NECROSIS , PARASITES , PATHOLOGY , PHYSIOLOGICAL EFFECTS , PROTOZOA


Subject Categories : Biology
      Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE