Accession Number : ADA625302


Title :   Osteoblast-Derived PTHRP and Breast Cancer Bone Metastasis


Descriptive Note : Final rept. 2 Sep 2003-1 Sep 2004


Corporate Author : MCGILL UNIV MONTREAL (CANADA)


Personal Author(s) : Karaplis, Andrew


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a625302.pdf


Report Date : Nov 2004


Pagination or Media Count : 41


Abstract : Metastases to bone, lung, and other organs are common and catastrophic consequences of breast cancer progression. There is therefore an urgent need to improve current therapies that address cancer growth and spread. Parathyroid hormone-related protein (PTHrP, also referred to as parathyroid hormone-like protein [PTHLP]) is a secreted factor expressed in almost all normal fetal and adult tissues, acting as an autocrine, paracrine, or intracrine factor in a wide range of developmental and physiological processes. Although PTHrP's dysregulated expression has traditionally been associated with oncogenic pathologies as the major causative agent of malignancy-associated hypercalcemia, recent evidence revealed a driving role in skeletal metastasis progression. Here, we demonstrate that PTHrP is also closely involved in breast cancer initiation, growth and metastasis to bone and lung through mechanisms separate from its bone turnover action, and we suggest that PTHrP as facilitator of oncogenes could serve as a novel target for therapeutic intervention.


Descriptors :   *BREAST CANCER , *METASTASIS , *PROTEINS , BONES , LUNG , MICE , MODELS , PARATHYROID GLANDS


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE