Accession Number : ADA623023


Title :   Inactivation of Bacillus Anthracis Spores Using Carbon Nanotubes


Descriptive Note : Final rept. 1 Jun 2010-31 May 2014


Corporate Author : NORTH CAROLINA CENTRAL UNIV DURHAM


Personal Author(s) : Yang, Liju


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a623023.pdf


Report Date : 30 Oct 2014


Pagination or Media Count : 12


Abstract : The Specific Aims of the project were to investigate: 1) the effect of single-walled carbon nanotubes (SWNTs) with different surface groups on the inactivation of B. anthracis spores; 2) the effect of SWNTs coupled with near-infrared (NIR) on B. anthracis spores; 3) the effect of SWNTs in combination with antimicrobial chemicals on inactivation of B. anthracis spores; 4) the effect of CNTs coated surfaces on the inactivation of B. anthracis spores; 5) the mechanisms of the inactivation effects of SWNTs to B. anthracis spores. Results of findings and their significance: We found that: 1) SWNTs were effective in inactivating B. anthracis cells, but not effective to B. anthracis spores. However, SWNTs can inhibit the biofilm formation from B. anthracis spores in suspension; 2) SWNTs coupled with oxidizing agents or near infrared laser enhanced its effect to inactivate B. anthracis spores; 3) Multi-well CNTs (MWNTS)-coated surfaces enhanced the attachment of B. anthracis spores, when in combination with natural peptide nisin, it can inhibit the biofilm formation from B. anthrancis spores. Overall, the project has resulted in 8 peer reviewed journal publications, 3 M.S. graduate student theses, a number of national conference presentations and student presentations/awards at college, university and local/regional conferences.


Descriptors :   *ANTIMICROBIAL AGENTS , *BACILLUS ANTHRACIS , *SPORES , ANTHRAX , CARBON NANOTUBES , CELLS(BIOLOGY) , COATINGS , COUPLING(INTERACTION) , GERMINATION , INACTIVATION , INFRARED LASERS , INHIBITION , NANOPARTICLES , NEAR INFRARED RADIATION , OXIDIZERS , PEPTIDES , SURFACE PROPERTIES


Subject Categories : Biochemistry
      Microbiology
      Biomedical Instrumentation and Bioengineering


Distribution Statement : APPROVED FOR PUBLIC RELEASE