Accession Number : ADA615424


Title :   Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells


Descriptive Note : Final rept. 1 Mar 2011-31 Aug 2014


Corporate Author : GENEVA FOUNDATION TACOMA WA


Personal Author(s) : Nussenzweig, Andre


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA615424


Report Date : Nov 2014


Pagination or Media Count : 82


Abstract : Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.


Descriptors :   *CELLS(BIOLOGY) , *GENOME , *MOLECULES , BREAST CANCER , DEOXYRIBONUCLEIC ACIDS , GENES , INHIBITION , INHIBITORS , INSTABILITY , IONIZING RADIATION , OVARIAN CANCER , PROTEINS , RECOMBINATION REACTIONS


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE