Accession Number : ADA614460


Title :   Echo-Planar Imaging-Based, J-Resolved Spectroscopic Imaging for Improved Metabolite Detection in Prostate Cancer


Descriptive Note : Annual rept. 30 Sep 2013-29 Sep 2014


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Thomas, Michael A


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA614460


Report Date : Oct 2014


Pagination or Media Count : 37


Abstract : Purpose: 1) To implement an echo-planar imaging (EPI)-based 2D J-resolved spectroscopy on a 3T MRI/MRS scanner;2) To evaluate the multi-voxel 2D J-resolved echo-planar spectroscopic imaging (EP-JRESI) in malignant PCa patients, benign prostatic hyperplasia (BPH) patients and healthy prostates. 3) To develop and further optimize the ProFit algorithm to postprocess the multi-dimensional MRS data from different prostate pathologies. Scope: Improved cancer detection (specificity) in differentiating malignant from benign prostate cancer will be achieved using a novel four-dimensional (4D) EP-JRESI. Improved spectroscopic imaging techniques will enable unambiguous detection of metabolites and the lipids in situ, which could potentially complement the existing diagnostic modalities commonly used in prostate cancer. Progress and Major Findings: After successful implementation of the 4D EP-JRESI sequence on a 3T MRI scanner, the 4D EP-JRESI data were recorded in several patients and healthy males during the first two years. Eleven more male subjects (6 patients and 5 healthy) were investigated using endorectal as well as external MRI coils and the findings are reproducible with that obtained in the past years. A manuscript was peer-reviewed by a leading MR journal during the last year.


Descriptors :   *MAGNETIC RESONANCE IMAGING , *METABOLITES , *PROSTATE CANCER , *SPECTROSCOPY , ANTIGENS , CANCER SCREENING , CHOLINES , CITRATES , CREATINE , FOUR DIMENSIONAL , RECTUM


Subject Categories : Biochemistry
      Medicine and Medical Research
      Atomic and Molecular Physics and Spectroscopy


Distribution Statement : APPROVED FOR PUBLIC RELEASE