Accession Number : ADA614459


Title :   A Putative Nononcogene Addiction Gene Target and Marker for Radiosensitivity in High-Risk Prostate Cancer


Descriptive Note : Final rept. 30 Sep 2011-29 Sep 2014


Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD


Personal Author(s) : Schaeffer, Edward M


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA614459


Report Date : Dec 2014


Pagination or Media Count : 12


Abstract : We proposed that RNASEH2A represents a novel type of gene, up-regulated in lethal prostate cancer to prevent catastrophic genomic instability and cell death and thereby acting to make prostate cancers resistant to treatment with radiation therapy. The major findings include (1) Expression of RNASEH2A in human prostate cancer cell lines. (2) Ability to modulate RNASEH2A expression genetically (3) Modulation of cell cycle, cell migration, transcription invasion and growth of prostate cancer cell lines with RNASEH2A. (4) Radio-resistance of prostate cancer cells that over express RNASEH2A. (5) Association of RNASEH2A with tumor grade. (6)Observation that RNASH2A expression does not independently predict lethal prostate cancer.(7)Observation that RNASH2A expression does predict radio-sensitivity and response to treatment in men who underwent radical prostatectomy and subsequently had post operative radiation.


Descriptors :   *GENES , *PROSTATE CANCER , *RADIATION TOLERANCE , CELLS(BIOLOGY) , GENE EXPRESSION , GENOME , NEOPLASMS , RADIOTHERAPY , RESISTANCE(BIOLOGY) , SIGNS AND SYMPTOMS , STABILITY


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE