Accession Number : ADA612308


Title :   Elucidation of Molecular Alterations in Precursor Lesions of Ovarian Serous Carcinoma


Descriptive Note : Final rept. 1 Jul 2009-30 Jun 2013


Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD


Personal Author(s) : Kurman, Robert J


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA612308


Report Date : Jul 2013


Pagination or Media Count : 8


Abstract : The objectives are to: 1) elucidate the pathogenesis of ovarian cancer by characterizing the early lesions, and 2) to provide biomarkers for early ovarian cancer detection. Both goals will be facilitated by the Consortium Development plan which is a collaborative, interdisciplinary program that will establish the infrastructure to coordinate research. The research sites include Johns Hopkins University, Toronto University, Memorial Sloan Kettering Cancer Center, and Yale University. The Coordination center will have three Cores. The specific goals to be accomplished are briefly summarized. The Administrative Core will collect IRB protocols from all research sites, organize the Consortium symposium including the Pathology/Epidemiology consensus meeting, setup and test the audio-video broad band electronic device for e-conference, organize the Internal Advisory Board. The Pathology/Epidemiology Core will define criteria for early ovarian cancer lesions and select cases/controls, survey available cases and controls from all research sites, create one overall database for specimens with clinical and epidemiologic data, establish tissue tracking mechanisms. The Biostatistics Core will establish the data collection, storage and security system, and perform statistics support in study design. The completion of these tasks is considered critical for us to continue our research in the coming Consortium research program.


Descriptors :   *EPIDEMIOLOGY , *LESIONS , *MUTATIONS , *OVARIAN CANCER , *PATHOGENESIS , BIOSTATISTICS , CLINICAL MEDICINE , DATA ACQUISITION , DATA BASES , MOLECULES , PRECURSORS , PREVENTION


Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE