Accession Number : ADA603894


Title :   The Role of Retinal Determination Gene Network (RDGN) in Hormone Signaling Transduction and Prostate Tumorigenesis


Descriptive Note : Annual rept. 30 Sep 2012-29 Sep 2013


Corporate Author : JEFFERSON MEDICAL COLL PHILADELPHIA PA


Personal Author(s) : Wu, Kongming


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a603894.pdf


Report Date : Oct 2013


Pagination or Media Count : 13


Abstract : Prostate cancer is the most frequent malignancy and the second leading cause of cancer-related death among men in the United States. Based on the unique characteristics that those prostate epithelia are dependent on androgen for growth and survival, androgen deprivation therapy (ADT) has been a first choice of prostate cancer treatment. Despite early success to suppress prostate tumor growth, ADT eventually fails leading to recurrent tumor growth in a hormone-refractory manner, even though AR remains to function in hormone-refractory prostate cancer. We identified a member of androgen receptor (AR) co-regulator, named dachshund (dac). dac was originally discovered as a dominant inhibitor of hyperactive growth factor receptors in genetic screens. RDGN pathway, consisting of the dachshund (dac), eyes absent (eya), eyeless, and sine oculis (so) (Six) genes DACH1 is structurally distinct to the current known tumor suppressors. We propose this unique function as a new type of tumor suppressor and refer to DACH1 as a commandeering tumor suppressor. Recently, we reported that expression of DACH1 is lost in human prostate cancer tissues and restoration of DACH1 inhibited ligand induced AR activity. Although the abnormal expressions of RDGN genes have been reported in prostate cancer, the precise role of RDGN in prostate cancer is not clear.


Descriptors :   *EYE , *GENES , *GROWTH(PHYSIOLOGY) , *HORMONES , *PROSTATE CANCER , *RETINA , ABNORMALITIES , ANDROGENS , EPITHELIUM , INHIBITORS , NEOPLASMS , PROSTATE GLAND , RECEPTOR SITES(PHYSIOLOGY) , SENSE ORGANS , TRANSDUCERS


Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE