Accession Number : ADA602648


Title :   Inherited Retinal Degenerative Clinical Trial Network. Addendum


Descriptive Note : Final addendum 30 Sep 2012-29 Sep 2013


Corporate Author : FOUNDATION FIGHTING BLINDNESS CLIINICAL RESEARCH INST COLUMB IA MD


Personal Author(s) : Zilliox, Patricia


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA602648


Report Date : Oct 2013


Pagination or Media Count : 21


Abstract : The Foundation Fighting Blindness Clinical Research Institute (FFB CRI) (Formerly National Neurovision Research Institute (NNRI), the clinical arm of the FFB, established the National Eye Evaluation Research (NEER) Network, composed of a collaborative group of five clinical treatment and evaluation centers. The intent of this network was to advance the science of therapeutic and preventative interventions for inherited orphan retinal degenerative diseases and dry age-related macular degeneration (AMD) through the conduct of clinical trials and other clinically relevant research. The scope of research carried out encompassed: (i) a phase II clinical trial to evaluate the safety and efficiency of new therapeutic and preventive approaches, by repurposing an FDA-approved small molecule drug; (ii) natural history studies to develop standardized criteria to define disease stage, severity and progression; (iii) observational studies to enhance understanding of the natural history of these diseases for different genotypes and phenotypes; and (iv) evaluation of the reliability and validity of different available treatment outcomes measures to determine those that are most appropriate for various genotypes and phenotypes as well as for specific interventions. The NEER Network also developed standard protocols for data collection maintained and expanded patient databases, classified by genotype and phenotype, which allowed for the timely identification of eligible patients and facilitate patient access for clinical participation and maintained readiness for collaboration with the Department of Defense, training program for military ophthalmologists in the latest technologies and diagnostic and treatment regimes.


Descriptors :   *CLINICAL TRIALS , *RETINA , DISEASES , DRUGS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE