Accession Number : ADA602466


Title :   Tissue Engineering of Dermal Blood and Lymphatic Microvascular Networks


Descriptive Note : Final rept. 1 Oct 2007-31 Dec 2010


Corporate Author : MISSOURI UNIV-COLUMBIA OFFICE OF SPONSORED PROGRAMS ADMINISTRATION


Personal Author(s) : Davis, George


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA602466


Report Date : 06 Mar 2014


Pagination or Media Count : 6


Abstract : This proposal focused on establishing the conditions necessary to induce lymphatic endothelial cell (EC) tube morphogenesis in 3D collagen matrices with the long-term goal of establishing separate networks of lymphatic tubes and co-existing, but not interconnecting networks of blood EC-lined tubes. In addition, we hoped that pericytes, which support blood EC tube networks, but not lymphatic vessel networks, would selectively recruit to one versus the other type of tube. Overall, we made progress, but did not identify the conditions that supported lymphatic tube morphogenesis over the long-term. We did identify some conditions that permitted early survival and some tube formation, but generally this did not persist over the long-term and there were not extensive tube networks observed.


Descriptors :   *BLOOD , *CARDIOVASCULAR SYSTEM , *LYMPHATIC SYSTEM , *TISSUES(BIOLOGY) , CELLS(BIOLOGY) , ENDOTHELIUM , MORPHOGENESIS


Subject Categories : Biology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE