Accession Number : ADA602417


Title :   Transportable Life Support for Treatment of Acute Lung Failure Due to Smoke Inhalation and Burns


Descriptive Note : Annual technical rept. 30 Mar 2013-29 Mar 2014


Corporate Author : GENEVA FOUNDATION TACOMA WA


Personal Author(s) : Batchinsky, Andriy


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a602417.pdf


Report Date : Apr 2014


Pagination or Media Count : 11


Abstract : This proposal compares 3 currently marketed extracorporeal gas exchange (ECGE) devices as means to treat lung failure. Objective: assess the capacity of the Hemolung, Cardiohelp and PECLA to lower injurious ventilator settings during transport of combat casualties with lung failure. Hypothesis: when used in conjunction with mechanical ventilation respiratory therapy with the Hemolung, or Cardiohelp, or PECLA permits a 50% or more reduction in minute ventilation. Specific aims: 1) Compare therapeutic efficiency of each ECGE device to reduce minute ventilation in model of ARDS due to smoke inhalation and burns in swine; 2) compare gas exchange efficiency and benchmark the ECGE devices; 3) compare expression of local (lung) and systemic inflammatory mediators; 4) assess safety of ECGE devices. Study design: prospective randomized study in 40 animals (10 for each device/group and controls).


Descriptors :   *INHALATION , *LUNG , *RESPIRATORY SYSTEM , *SMOKE , *VENTILATORS , CASUALTIES , CONTROL , EFFICIENCY , FAILURE , GAS EXCHANGE(BIOLOGY) , HYPOTHESES , LIFE SUPPORT SYSTEMS , MECHANICAL PROPERTIES , REDUCTION , SAFETY , STANDARDS , THERAPY , TRANSPORT , TRANSPORTABLE , VENTILATION


Subject Categories : Medicine and Medical Research
      Air Condition, Heating, Lighting & Ventilating
      Life Support Systems


Distribution Statement : APPROVED FOR PUBLIC RELEASE