Accession Number : ADA597808


Title :   A New Classification System for the Actions of IRS Chemicals Traditionally Used for Malaria Control


Descriptive Note : Journal article


Corporate Author : UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF PREVENTIVE MEDICINE AND BIOMETRICS


Personal Author(s) : Grieco, John P ; Achee, Nicole L ; Chareonviriyaphap, Theeraphap ; Suwonkerd, Wannapa ; Chauhan, Kamal ; Sardelis, Michael R ; Roberts, Donald R


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA597808


Report Date : 08 Aug 2007


Pagination or Media Count : 12


Abstract : Knowledge of how mosquitoes respond to insecticides is of paramount importance in understanding how an insecticide functions to prevent disease transmission. A suite of laboratory assays was used to quantitatively characterize mosquito responses to toxic, contact irritant, and non-contact spatial repellent actions of standard insecticides. Highly replicated tests of these compounds over a range of concentrations proved that all were toxic, some were contact irritants, and even fewer were non-contact repellents. Of many chemicals tested, three were selected for testing in experimental huts to confirm that chemical actions documented in laboratory tests are also expressed in the field. The laboratory tests showed the primary action of DDT is repellent, alphacypermethrin is irritant, and dieldrin is only toxic. These tests were followed with hut studies in Thailand against marked-released populations. DDT exhibited a highly protective level of repellency that kept mosquitoes outside of huts. Alphacypermethrin did not keep mosquitoes out, but its strong irritant action caused them to prematurely exit the treated house. Dieldrin was highly toxic but showed no irritant or repellent action. Based on the combination of laboratory and confirmatory field data, we propose a new paradigm for classifying chemicals used for vector control according to how the chemicals actually function to prevent disease transmission inside houses. The new classification scheme will characterize chemicals on the basis of spatial repellent, contact irritant and toxic actions.


Descriptors :   *CHEMICALS , *CLASSIFICATION , *CULICIDAE , *INSECTICIDES , *MALARIA , DDT , DIELDRIN , INFECTIOUS DISEASE TRANSMISSION , IRRITATING AGENTS , LABORATORY TESTS , REPELLENTS , RESIDUALS , SPATIAL DISTRIBUTION , SPRAYS , TOXICITY


Subject Categories : Information Science
      Biology
      Medicine and Medical Research
      Inorganic Chemistry
      Pesticides Pollution and Control


Distribution Statement : APPROVED FOR PUBLIC RELEASE