Accession Number : ADA594876


Title :   Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions


Descriptive Note : Annual rept. 15 Jul 2012-14 Jul 2013


Corporate Author : MICHIGAN UNIV ANN ARBOR


Personal Author(s) : El-Sayed, Mohamed


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA594876


Report Date : Aug 2013


Pagination or Media Count : 47


Abstract : We report the synthesis of the amphiphilic PEG-b (PAA)-b-P(HDFMA-co-MMA) copolymers that proved to encapsulate 1%-2% v/v PFP forming nanodroplets. Combining these nanodroplets with histotripsy proved to generate a cavitation bubble cloud with similar behavior but lower pressure compared to histotripsy itself. Moreover, these nanodroplets maintained their average size and concentration upon incubation with BSA for 24 hours at 37 degrees celcius, which prove their promise for cancer cell ablation and warrant their future testing in vivo.


Descriptors :   *PROSTATE CANCER , ABLATION , BEHAVIOR , BUBBLES , CAVITATION , IMAGES , IN VIVO ANALYSIS , INCUBATION , LESIONS , LOW PRESSURE , SYNTHESIS , ULTRASONICS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE