Accession Number : ADA593126


Title :   Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR4)


Descriptive Note : Annual rept. 30 Sep 2012-29 Sep 2013


Corporate Author : COLORADO UNIV AT BOULDER


Personal Author(s) : Watkins, Linda R ; Maier, Steven ; Bachtell, Ryan ; Katz, Jonathan ; Diamond, Betty


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA593126


Report Date : Oct 2013


Pagination or Media Count : 18


Abstract : This project is progressing excellently and remains on schedule across research sites as defined by the Statement of Work. From studies completed to date, our major findings are that (a) morphine-induced increases in extracellular dopamine in the Nucleus Accumbens (NAc) shell is suppressed by microinjection of the toll like receptor 4 (TLR4) antagonist LPS-RS into either the NAc or the ventral tegmental area (VTA). Intriguingly, suppression of NAc dopamine in response to cocaine is also observed by NAc or VTA LPS-RS. This is exciting as it challenges the broadly held view that the major effect of cocaine is on dopamine transporters in the VTA. Given this intriguing result, a control study was undertaken to ensure specificity of the results obtained. Specificity was observed since LPS-RS had no effect on dopamine released in response to intra-VTA neurotensin. Multiple additional Aims and SubAims have begun and significant progress anticipated in the coming project period.


Descriptors :   *DRUG ABUSE , *DRUG ADDICTION , *RECEPTOR SITES(PHYSIOLOGY) , COCAINE , CONTROL , DOPAMINE , MORPHINE , RESPONSE , SCHEDULING , SENSE ORGANS , SITES , SUPPRESSION


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE