Accession Number : ADA592990


Title :   Early Detection of Breast Cancer Using Posttranslationally Modified Biomarkers


Descriptive Note : Annual summary rept. 1 Mar 2012-30 Aug 2013


Corporate Author : BATTELLE MEMORIAL INST RICHLAND WA PACIFIC NORTHWEST LABS


Personal Author(s) : Jin, Hongjun


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA592990


Report Date : Sep 2013


Pagination or Media Count : 50


Abstract : In this project, we focus on oxidation and glycosylation PTMs on proteins known to be secreted by the breast as candidate biomarkers for the early detection of breast cancer. ELISA microarray technology has employed to evaluate assays that have potential be used as breast cancer biomarkers. During the third year of this project we have continued the validation for our PTM-ELISA microarray. And we validated the chosen PTM antibody for pre-clinical or translational molecular imaging studies. The microPET imaging suggested that those PTM antibodies have high specific accumulation for breast cancer in tumor xenograft mice. Overall, our data suggest that the PTM ELISA microarray platform is a promising tool for discovery and evaluation of biomarkers that have potential for the early detection of breast cancer.


Descriptors :   *BREAST CANCER , *POSITRON EMISSION TOMOGRAPHY , ANTIBODIES , CLINICAL MEDICINE , DETECTION , GLYCOSIDES , MAMMARY GLANDS , NEOPLASMS , PROTEINS , TEST AND EVALUATION , TOOLS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE