Accession Number : ADA592878


Title :   Phosphoramidate-based Peptidomimetic Prostate Cancer PET Imaging Agents


Descriptive Note : Annual rept. 20 Jun 2011-31 Aug 2013


Corporate Author : CALIFORNIA UNIV SAN FRANCISCO


Personal Author(s) : Dannoon, Shorouk F


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA592878


Report Date : Nov 2013


Pagination or Media Count : 23


Abstract : The main goal is to develop a PET imaging agent based on modifying the peptidomimetic PSMA inhibitor which will result in improved tumor uptake and clearance mechanism. Different fluorination approaches were attempted with PSMA module compounds such as direct labeling, cupper free chemistry and the use of prosthetic group (SFB). The direct labeling approach has been eliminated as an option due to the instability of the fluorination. As for the cupper free chemistry labeling approach, the final purification step is in progress to provide a final product with higher specific activity (less mass for better imaging). In addition, the production of SFB has been attempted for labeling the module compounds as well and the work is ongoing. Once the labeling approaches are established, and then the labeling of the modified PSMA inhibitor analogues will be investigated in vitro as well as in vivo.


Descriptors :   *PEPTIDES , *POSITRON EMISSION TOMOGRAPHY , *PROSTATE CANCER , ANTIGENS , FLUORINE , LABELED SUBSTANCES , MEMBRANES(BIOLOGY) , PURIFICATION


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE