Accession Number : ADA592574


Title :   FES-Rowing versus Zoledronic Acid to Improve Bone Health in SCI


Descriptive Note : Revised annual rept. 30 Sep 2011-29 Sep 2012


Corporate Author : SPAULDING REHABILITATION HOSPITAL BOSTON MA


Personal Author(s) : Morse, Leslie R


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a592574.pdf


Report Date : Oct 2012


Pagination or Media Count : 8


Abstract : There is no established treatment to prevent bone loss or to induce new bone formation following SCI, although the risk is high in this population of osteoporosis-related bone fracture. This study aims to learn if the severe osteoporosis in lower extremities caused by spinal cord injuries can be slowed or reversed with a combination of an exercise that simulates weight-bearing and a bisphosphonate medication. 70 Individuals with T3-12 spinal cord injuries will be enrolled in a 12-month regime of adapted FES-rowing. Our preliminary study findings demonstrated this exercise led to new bone formation and improved bone micro architecture in the lower extremities of people with SCI. Half of the subjects also receive a bisphosphonate medication known to slow bone loss, but not stimulate bone renewal. Participant recruitment began in late February, 2011, and is continuing. We have enrolled 47 subjects who are at various stages of the study protocol. At this point, there are no significant findings to report.


Descriptors :   *BONES , *HEALTH , ACIDS , BONE FRACTURES , OSTEOPOROSIS , REVERSIBLE , RISK , SPINAL CORD , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE