Accession Number : ADA591294

Title :   Cyanide Antidotes for Mass Casualties: Comparison of Intramuscular Injector by Autoinjector, Intraosseous Injection, and Inhalational Delivery

Descriptive Note : Annual rept. 26 Sep 2012-25 Sep 2013

Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s) : Boss, Gerry R

Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a591294.pdf

Report Date : Oct 2013

Pagination or Media Count : 10

Abstract : Current antidotes for cyanide poisoning must be administered by intravenous injection, which would not be practical for treating mass casualties as could occur in a major industrial accident or a terrorist attack. Thus, a need exists for alternative modes of administering cyanide antidotes, and we are comparing three different administration modes: intramuscular injection via an autoinjector, intraosseous injection, and inhalational delivery. We have found that all three modes can rescue animals from exposure to lethal cyanide doses, and now need to determine which administration mode would be the most practical for treating a large number of cyanide-poisoned persons.

Descriptors :   *ANTIDOTES , *CYANIDES , *EXPOSURE(PHYSIOLOGY) , *POISONING , ANIMALS , BONES , DOSAGE , INJECTIONS(MEDICINE) , INTRAMUSCULAR INJECTIONS , RESCUES

Subject Categories : Biochemistry
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE