Accession Number : ADA590500


Title :   Genetic Modifiers of Ovarian Cancer


Descriptive Note : Annual rept. 15 May 2012-14 May 2013


Corporate Author : MAYO CLINIC ROCHESTER MN


Personal Author(s) : Couch, Fergus J


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA590500


Report Date : Jun 2013


Pagination or Media Count : 9


Abstract : Individuals with germline mutations in BRCA1 have an elevated but incomplete risk of developing ovarian cancer suggesting the presence of genetic modifiers of ovarian cancer in this population. A genome wide association study (GWAS) for ovarian cancer in BRCA1 mutation carriers has identified several novel modifiers of ovarian cancer risk for BRCA1 mutation carriers that can be used for individualized ovarian cancer risk assessment.


Descriptors :   *GENES , *MUTATIONS , *OVARIAN CANCER , GENOME , NEOPLASMS


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE