Accession Number : ADA583965


Title :   Developing Novel Automated Apparatus for Studying Battery of Social Behaviors in Mutant Mouse Models for Autism


Descriptive Note : Final rept. 9 May 2011-8 May 2013


Corporate Author : WEIZMANN INST OF SCIENCE REHOVOT (ISRAEL)


Personal Author(s) : Kimchi, Tali


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a583965.pdf


Report Date : Jun 2013


Pagination or Media Count : 21


Abstract : We have constructed general-purpose, automated, quantitative behavioral phenotyping platform for cohort socially interacting group of mice. The system is designed for identification and quantification of a large battery of locomotion and social behavioral traits potentially relevant to the symptoms of autism and other social-related mental disorders. Importantly, the systems are designed to remotely record mouse behavior day and night on much longer time scales than traditionally assayed, and to provide the tested animals with ecologically-relevant experimental conditions. We demonstrate the usefulness of this data in characterizing individual phenotypes, interactions between pairs and the collective social organization of groups. Since our experimental platform poses no significant size or structure constraints, it can be readily adjusted to enable a wide range of multi-purpose, stable measurements on diverse animal research models.


Descriptors :   *BEHAVIOR , *BRAIN FUNCTION IMPAIRMENT , *SOCIAL PSYCHOLOGY , BRAIN , IDENTIFICATION , INTERACTIONS , ISRAEL , MEASUREMENT , MUTATIONS , NIGHT , SIGNS AND SYMPTOMS


Subject Categories : Psychology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE