Accession Number : ADA578633


Title :   High Resolution PET Imaging Probe for the Detection, Molecular Characterization and Treatment Monitoring of Prostate Cancer


Descriptive Note : Final rept. 1 Jul 2009-30 Jun 2012


Corporate Author : MICHIGAN UNIV ANN ARBOR


Personal Author(s) : Clinthorne, Neal H ; Majewski, Stan


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA578633


Report Date : Jul 2012


Pagination or Media Count : 56


Abstract : The goal of this work was to improve PET instrumentation used for molecular imaging in prostate cancer with applications to diagnosis, guiding biopsy, planning treatment and monitoring therapy. The goal was achieved by developing the concept of dedicated endorectal PET probes that provide significant improvements in image quality over conventional, external-ring PET alone. Using newly available silicon photomultiplier technology, several probe detectors were developed. It was predicted, and subsequently shown, that probes having good position resolution in 3D would be important. Through the use of simulation and phantom imaging studies, these devices demonstrated the potential for obtaining high spatial resolution for prostate imaging. Practical proof-of-concept detectors with good depth-of-interactions resolution have been developed and tested. The most desirable next step will be to integrate these probes with commercial PET/MRI systems for human subjects testing.


Descriptors :   *POSITRON EMISSION TOMOGRAPHY , *PROSTATE CANCER , MONTE CARLO METHOD , PERFORMANCE TESTS , PROBES , PROTOTYPES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE