Accession Number : ADA567967


Title :   Echo-Planar Imaging Based J-Resolved Spectroscopic Imaging for Improved Metabolite Detection in Prostate Cancer


Descriptive Note : Annual rept. 30 Sep 2011-29 Sep 2012


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Thomas, Michael A


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA567967


Report Date : Oct 2012


Pagination or Media Count : 41


Abstract : To implement an echo-planar imaging (EPI)-based 2D J-resolved spectroscopy on a 3T MRI/MRS scanner;2) To evaluate the multi-voxel 2D J-resolved echo-planar spectroscopic imaging (EP-JRESI) in malignant PCa patients, benign prostatic hyperplasia (BPH) patients and healthy prostates. 3) To develop and further optimize the ProFit algorithm to postprocess the multi-dimensional MRS data from different prostate pathologies. Scope: A major outcome is expected to be on improved detection (specificity) in differentiating malignant from benign prostate cancer using a novel four-dimensional (4D) EP-JRESI. Improved spectroscopic imaging techniques will enable unambiguous detection of metabolites and the lipids in situ, which could potentially complement the existing diagnostic modalities commonly used in prostate cancer. Progress and Major Findings: The 4D EP-JRESI sequence was successfully implemented on a 3T MRI scanner using the Siemens IDEA pulse sequence compiler and multi-voxel 2D J-resolved spectra have been recorded using external as well as endorectal MRI coils. Endo-rectal 4D EP-JRESI data have been successfully recorded in 24 prostate cancer patients. Three peer-reviewed manuscripts have been published during the first year


Descriptors :   *PROSTATE CANCER , DIAGNOSIS(MEDICINE) , LIPIDS , METABOLITES , SPECTROSCOPY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE