Accession Number : ADA566089


Title :   In Search of an Effective in vivo Reactivator for Organophosphorus Nerve Agent-Inhibited Acetylcholinesterase in the Central Nervous System


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD PHARMACOLOGY BRANCH


Personal Author(s) : Shih, Tsung-Ming ; Koplovitz, Irwin ; Kan, Robert K ; McDonough, John H


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA566089


Report Date : Jan 2012


Pagination or Media Count : 29


Abstract : Organophosphorus nerve agents irreversibly inhibit the enzyme acetylcholinesterase (AChE), leading to excessive cholinergic neurotransmission and causing toxic lethal consequences. Current nerve agent therapies in the U.S. include 2-pralidoxime to reactivate inhibited AChE. Due to its quaternary structure, this oxime does not readily cross the blood brain barrier (BBB) to reactivate brain AChE and to mitigate CNS toxicity.


Descriptors :   *ACETYLCHOLINESTERASE , *CENTRAL NERVOUS SYSTEM , BRAIN , CHOLINESTERASE , GB AGENT , LABORATORY ANIMALS , NERVE AGENTS , ORGANIC PHOSPHORUS COMPOUNDS , OXIMES , REPRINTS , VX AGENT


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE