Accession Number : ADA564160


Title :   Role of Receptor Sialylation in the Ovarian Tumor Cell Phenotype


Descriptive Note : Annual rept. 15 May 2011-14 May 2012


Corporate Author : ALABAMA UNIV IN BIRMINGHAM


Personal Author(s) : Bellis, Susan L


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA564160


Report Date : Jun 2012


Pagination or Media Count : 8


Abstract : The overarching goal of our research is to define the role of a cancer-associated glycosyltransferase, ST6Gal-I, in regulating the ovarian tumor cell phenotype. In the first year of this pilot project, significant progress has been made toward establishing ST6Gal-I s function in protecting tumor cells from apoptosis. These results establish a new paradigm in apoptotic signaling, particularly given that there is a marked dearth of evidence concerning glycosylation-dependent mechanisms in tumor cell survival. We also show that tumor cells can be sensitized to cisplatin-induced cell death through forced downregulation of ST6Gal-I. Platin drugs represent a first-line treatment for ovarian cancer, therefore therapeutic targeting of ST6Gal-I may hold promise for treating patients that have become chemoresistant. Finally, preliminary results indicate that ST6Gal-I protein is upregulated in human ovarian tumors, implicating ST6Gal-I as a potential new biomarker. In the upcoming year, our studies will focus on elucidating the mechanistic basis by which ST6Gal-I modulates the activity of integrins and death receptors to control tumor cell invasion and apoptosis-resistance.


Descriptors :   *CELLS(BIOLOGY) , *OVARIAN CANCER , *RECEPTOR SITES(PHYSIOLOGY) , APOPTOSIS , DEATH , DRUGS , METASTASIS , NEOPLASMS , OVARIES , PATIENTS , THERAPY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE