Accession Number : ADA560887


Title :   Regulation of the Prostate Cancer Tumor Microenvironment


Descriptive Note : Annual summary rept. 15 Mar 2011-14 Mar 2012


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Chin, Arnold I


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA560887


Report Date : Apr 2012


Pagination or Media Count : 8


Abstract : Toll-like receptors (TLRs) are key signaling molecules that regulate innate and adaptive immune responses to the presence of pathogens. The role of TLRs in cancer is unclear. During our first year of this training proposal, we are expanding transgenic and transgenic crosses to various TLR signaling molecules for Specific Aims 1 and 2. We have generated TRAMP Tg+/- x MyD88-/- mice. Initial results reveal that de novo prostate cancers in absence of MyD88 are larger with higher grade adenocarcinomas than wild-type controls. Analysis of tumor infiltrating cells reveals increased infiltrating macrophage lineage in the absence of MyD88. We are in the process of understanding the activation of signaling pathways, local and systemic cytokine levels, and other infiltrating cell types that may modulate the differences in tumor development. We are also isolating TRAMP Tg/- cell lines deficient in MyD88 to ascertain the role of MyD88 in the intrinsic growth of TRAMP prostate cancer cells.


Descriptors :   *CYTOKINES , *PROSTATE CANCER , ADAPTIVE SYSTEMS , CELLS(BIOLOGY) , GROWTH(PHYSIOLOGY) , IMMUNITY , MACROPHAGES , NEOPLASMS , PROSTATE GLAND , RESPONSE(BIOLOGY) , SIGNALS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE