Accession Number : ADA560653


Title :   Hematopoiesis Primer Modeling Combined Injury


Descriptive Note : Technical rept. Dec 2010-2012


Corporate Author : APPLIED RESEARCH ASSOCIATES INC ARLINGTON VA


Personal Author(s) : Pellmar, Terry C ; Reeves, Glen I


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA560653


Report Date : May 2012


Pagination or Media Count : 34


Abstract : This report is an overview of the basic principles underlying the formation, function, and response to injury of the different elements of the hematopoietic system. The adverse effects of radiation on the hematopoietic system differ from those of thermal burn or traumatic wounding. In turn, the effects of burn injury and trauma with hemorrhage differ from one another. Accordingly, the effects of individual injurious modality on each hematopoietic element are considered. The cell kinetics of myelopoiesis under irradiation are used in the current model of Radiation-Induced Performance Decrement (RIPD) to estimate lethality. This report is also intended to highlight potential roles for hematopoietic effects in the new models of RIPD to incorporate findings in recent assessments of changes of blood cells in combined injury models (combined injury being defined as radiation injury plus burn or wound trauma injury, or both).


Descriptors :   *HEMATOPOIESIS, *HEMATOPOIETIC SYSTEM, *TRAUMA, *WOUNDS AND INJURIES, ADVERSE CONDITIONS, BLOOD CELLS, BURNS(INJURIES), HEMORRHAGE, IRRADIATION, KINETICS, RADIATION INJURIES, REPORTS, TEST AND EVALUATION, THERMAL RADIATION


Subject Categories : Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE