Accession Number : ADA548163


Title :   Respiratory Challenges in Breast Cancer: Potential for Enhanced Diagnostics and Therapy


Descriptive Note : Annual rept. 1 Jul 2008-30 Jun 2009


Corporate Author : BECKMAN LASER INST AND MEDICAL CLINIC IRVINE CA


Personal Author(s) : Kim, Jae G.


Report Date : 31 JUL 2009


Pagination or Media Count : 0


Abstract : For the first year of this project, I took the trainings that are necessary to perform this study and have started to monitor the changes in endogenous tissue chromophores such as oxy-, deoxy-, total hemoglobin concentration, tissue oxygen saturation, lipid and water contents during tumor growth and chemotherapy using a diffuse optical imaging system that we developed at Beckman Laser Institute. We also started to monitor the changes of endogenous chromophores during chemotherapy using a spontaneous mice breast tumor model. During the optical imaging measurements, we switched a breathing gas from air to 100% oxygen and measured the changes in endogenous chromophores. Our results showed that oxy and total hemoglobin concentration increased as tumor grows and decreased when tumors regress due to chemotherapy and also showed that scattering map can help to identify tumor location. Breathing gas intervention from air to 100% oxygen increased oxyhemoglobin and decreased deoxyhemoglobin and thus increased tissue oxygen saturation. The changes during oxygen gas intervention were significantly different between chemotherapy responding tumors versus non responding tumors in the spontaneous mice breast tumor model. These results tell us that hyperoxic gas intervention can enhance the detection of tumor and also possibly predict tumor response to the treatment.


Descriptors :   *BREAST CANCER , *NEOPLASMS , *RESPIRATORY SYSTEM , BREATHING GASES , CHEMOTHERAPY , CHROMOPHORES , CONCENTRATION(COMPOSITION) , DETECTION , DIAGNOSIS(GENERAL) , GROWTH(GENERAL) , HEMOGLOBIN , INTERVENTION , LIPIDS , MEASUREMENT , MEDICAL SERVICES , MODELS , OPTICAL EQUIPMENT , OPTICAL IMAGES , OPTICS , OXYGEN , RESPONSE , TISSUES(BIOLOGY)


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE