Accession Number : ADA547245


Title :   Specific PET Imaging Probes for Early Detection of Prostate Cancer Metastases


Descriptive Note : Annual rept. 1 May 2010-30 Apr 2011


Corporate Author : TEXAS UNIV AT DALLAS


Personal Author(s) : Sun, Xiankai


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA547245


Report Date : MAY 2011


Pagination or Media Count : 21


Abstract : The ultimate goal of this project is to develop specific PET imaging probes for early detection of distal metastases of prostate cancer. Based on one of our studies using a polyarginine (NH2GR11) to deliver a therapeutic moiety to various prostate cancer cell lines, we hypothesize a new group of prostate-specific peptides could be developed as novel PET imaging probes using NH2GR11 as a lead compound for the detection of multi-foci extraprostatic spread of prostate cancer. Three specific aims are arranged to achieve the goals of this proposal: (1) Determine the mechanism of the prostate-specific uptake exhibited by NH2GR11; (2) Design and synthesize novel BFC-peptide conjugates to achieve desired in vivo stability, pharmacokinetics, and enhanced prostate-specific binding affinity; and (3) Establish radiochemical protocols to label peptide conjugates with 64 Cu, and perform in vitro/in vivo evaluations of the potential prostate cancer-specific imaging agents.


Descriptors :   *POSITRON EMISSION TOMOGRAPHY , *PROSTATE CANCER , *METASTASIS , *RECEPTOR SITES(PHYSIOLOGY) , *PEPTIDES , ONCOGENESIS , PHARMACOKINETICS , IN VITRO ANALYSIS , DETECTION , IN VIVO ANALYSIS


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE