Accession Number : ADA545593


Title :   Screening and Selection of New Antagonists of the RING-Mediated Hdm2/Hdmx Interaction


Descriptive Note : Annual rept. 1 Mar 2010-28 Feb 2011


Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES


Personal Author(s) : Camerero, Julio A.


Report Date : MAR 2011


Pagination or Media Count : 126


Abstract : During the first period of the grant we have been able: 1) Produce large libraries (106 different cyclotides) of cyclotides in E. coli cells using the loop 2 of the cylotide MCoTI-I (Specific aim #1, Task 2a) 2) We have cloned, expressed and characterized a fluorogenic reporter to screen in-cell cyclotide libraries for inhibitors of the RING-mediated interaction between Mdm2/MdmX (specific aim #1, Task 1a & 1b).


Descriptors :   *PROSTATE CANCER , *PHARMACOLOGICAL ANTAGONISTS , *PUBLIC HEALTH , APOPTOSIS , LIBRARIES , DEATH , CLONES , ESCHERICHIA COLI , CELLS(BIOLOGY)


Subject Categories : MEDICINE AND MEDICAL RESEARCH
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE