Accession Number : ADA545593
Title : Screening and Selection of New Antagonists of the RING-Mediated Hdm2/Hdmx Interaction
Descriptive Note : Annual rept. 1 Mar 2010-28 Feb 2011
Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
Personal Author(s) : Camerero, Julio A.
Report Date : MAR 2011
Pagination or Media Count : 126
Abstract : During the first period of the grant we have been able: 1) Produce large libraries (106 different cyclotides) of cyclotides in E. coli cells using the loop 2 of the cylotide MCoTI-I (Specific aim #1, Task 2a) 2) We have cloned, expressed and characterized a fluorogenic reporter to screen in-cell cyclotide libraries for inhibitors of the RING-mediated interaction between Mdm2/MdmX (specific aim #1, Task 1a & 1b).
Descriptors : *PROSTATE CANCER , *PHARMACOLOGICAL ANTAGONISTS , *PUBLIC HEALTH , APOPTOSIS , LIBRARIES , DEATH , CLONES , ESCHERICHIA COLI , CELLS(BIOLOGY)
Subject Categories : MEDICINE AND MEDICAL RESEARCH
Distribution Statement : APPROVED FOR PUBLIC RELEASE