Accession Number : ADA542531


Title :   Targeted Analysis of KLF6/KLF6-SV1 Regulating Pathways in Prostrate Cancer Development and Metastasis


Descriptive Note : Annual summary rept. 10 Aug 2009-14 Aug 2010


Corporate Author : MOUNT SINAI SCHOOL OF MEDICINE NEW YORK


Personal Author(s) : Rodriguez-Burgos, Rosa E


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a542531.pdf


Report Date : Sep 2010


Pagination or Media Count : 53


Abstract : KLF6 is a member of the Kruppel-like transcription factor family and it was first identified as a tumor suppressor gene frequently inactivated in Prostate cancer (PCa) (1, 2). A single germline SNP increases PCa risk and KLF6 gene alternative splicing to produce KLF6-SV1, which promotes tumor cell growth and metastasis (3, 4, 5). Since KLF6 was first discovered many downstream, cancer-relevant targets have since been described to be regulated by KLF6 and KLF6-SV1 (1, 6-11). However, less is known about the molecular pathways that regulate the function of these proteins. Therefore, the main purpose of this project is to identify the molecular pathways by which KLF6/KLF6-SV1 are involved in the initiation, progression and metastasis of PCa.


Descriptors :   *METASTASIS , *PROSTATE CANCER , NEOPLASMS , HORIZONTAL ORIENTATION , CELLS(BIOLOGY) , PROTEINS , RISK , GENES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE