Accession Number : ADA539932


Title :   Progression of Ocular Sulfur Mustard Injury: Development of a Model System


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD


Personal Author(s) : Milhorn, Denise ; Hamilton, Tracey ; Nelson, Marian ; McNutt, Patrick


Report Date : 2010


Pagination or Media Count : 10


Abstract : Exposure of tissues to sulfur mustard (SM) results in the formation of protein and nucleotide adducts that disrupt cellular metabolism and cause cell death. Subsequent pathologies involve a significant pro inflammatory response, disrupted healing, and long-term defects in tissue architecture. Following ocular exposure, acute corneal sequelae include epithelial erosions, necrosis, and corneal inflammation. Longer term, a progressive injury becomes distributed throughout the anterior chamber, which ultimately causes a profound remodeling of corneal tissues. In many cases, debilitating and vision-threatening injuries reoccur months to years after the initial exposure. Preliminary data in humans suffering from chronic epithelial lesions suggest that thymosin 134 (Ti34) may be a viable candidate to mitigate acute or long-term ocular SM injury. To evaluate therapeutic candidates, we have developed a rabbit ocular exposure model system. In this paper, we report molecular, histological, ultrastructural, and clinical consequences of rabbit ocular SM injury, which can be used to assess Ti34 efficacy, including timepoints at which Ti34 will be assessed for therapeutic utility.


Descriptors :   *HD AGENT , *WOUNDS AND INJURIES , *MUSTARD AGENTS , *CORNEA , INFLAMMATION , LESIONS , HEALING , NECROSIS , RABBITS , NUCLEOTIDES , CELLS(BIOLOGY) , EYE , MODELS , EPITHELIUM , TISSUES(BIOLOGY)


Subject Categories : MEDICINE AND MEDICAL RESEARCH
      CHEMICAL, BIOLOGICAL AND RADIOLOGICAL WARFARE


Distribution Statement : APPROVED FOR PUBLIC RELEASE