Accession Number : ADA529422


Title :   Magnetic Responsive Hydrogel Material Delivery System II


Descriptive Note : Final rept. 17 Jun 2009-17 Jul 2010


Corporate Author : KYUNGPOOK NATIONAL UNIV DAEGU (SOUTH KOREA) DEPT OF POLYMER SCIENCE


Personal Author(s) : Park, Soo-Young


Report Date : 29 AUG 2010


Pagination or Media Count : 25


Abstract : We have developed a novel route for the synthesis of the thermoresponsive core-shell nanoparticles that consist of the magnetite core and the poly(N-isoproplyacrylamide) (poly(NIPAAm) shell in aqueous medium. Magnetic nanoparticles (MNPs) were coated with first oleic acid (OA) and then vinyl carboxylic acid-beta-cyclodextrin (MAH-beta-CD). The OA-MNPs and the MAH-beta-CD-MNPs showed mono-dispersion in a n-hexane and aqueous medium, respectively. NIPAAms were successfully polymerized from the vinyl double bonds of the MAH-beta-CD MNPs and cross-linked with N, N-methylenebisacrylamide (MBA) to make the stable thermo-responsive core-shell morphology with the MNP core and the poly(NIPAAm) shell (poly(NIPAAm)-MNP). The aqueous solutions dispersed with poly (NIPAAm)-MNPs showed magnetic heating due to a super paramagnetic property, and the poly (NIPAAm) shell shrank above its LCST temperature. Apart from aqueous dispersed solution PNIPAAm magnetite composite film can also be prepared via photopolymerization using APS as a photo initiator. The film synthesized is cross linked with MBA and thus insoluble in water. When AC magnetic field is applied on such a PNIPAAm nanocomposite film, MNPS oscillate and produce heat and as a result PNIPAAm shrinkage can be observed. The combination of these properties are potentially important in target delivery of therapeutic agent in vivo, hyperthermic treatment of tumors, magnetic resonance imaging (MRI) as contrasting agents, tissue repair, immunoassay, cell separation, biomagnetic separation of biomolecules, etc.


Descriptors :   *BIOMAGNETISM , *POLYMERIZATION , *NANOPARTICLES , *VINYL PLASTICS , BIOMOLECULES , PARAMAGNETISM , OLEIC ACID , PHOSPHORUS ALLOYS , MAGNETIC RESONANCE IMAGING , AQUEOUS SOLUTIONS , TUNGSTEN ALLOYS , NEOPLASMS , PHOTOCHEMICAL REACTIONS , MAGNETIC FIELDS , MAGNETIC PROPERTIES


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH
      POLYMER CHEMISTRY
      ELECTRICITY AND MAGNETISM
      BIONICS


Distribution Statement : APPROVED FOR PUBLIC RELEASE