Accession Number : ADA526009


Title :   Androgen, Estrogen and the Bone Marrow Microenvironment


Descriptive Note : Final rept. 29 Nov 2005-28 Nov 2009


Corporate Author : FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA


Personal Author(s) : Knudsen, Beatrice


Report Date : DEC 2009


Pagination or Media Count : 21


Abstract : We have accomplished the following: 1) Characterized androgen responsive genes in mouse bone marrow (BM) via castration (androgen ablation) and estrogen stimulation. 2) Measurements of testosterone, dihydrotestosterone and of genes that regulate the local androgenconcentration in samples of human bone marrow. 3) Generating a human model system for studies of androgen regulation of the bone marrow stroma and its effects on cancer cells. 4) Established a 3D system of bone marrow stromal cells and DU145 cancer cells; we report the outcomes that are relevant to each of the tasks listed in the grant: We are organizing the animal work for the human bone marrow xenograft studies in mice by generating the appropriate stromal cell line/androgen response system and determining the most


Descriptors :   *BONE MARROW , *ANDROGENS , CELLS(BIOLOGY) , TESTOSTERONE , PROSTATE GLAND , ESTROGENS , GENES , TISSUES(BIOLOGY)


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE