Accession Number : ADA487437


Title :   Estrogen Metabolism and Prostate Cancer Risk: A Prospective Study


Descriptive Note : Annual rept. 1 May 2006-30 Apr 2007


Corporate Author : ITALIAN NATIONAL CANCER INST REGINA ELENA ROME (ITALY)


Personal Author(s) : Muti, Paola


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a487437.pdf


Report Date : May 2007


Pagination or Media Count : 23


Abstract : Prostate cancer is the most common cancer among men in the United States (IARC, 1995) and the second most common in the European Community (IARC, 1995). The causes of prostate cancer, however, remain largely unknown, with age, race, and family history being the only established risk factors (Nomura et al., 1997). The prostate gland has historically been considered the prototype of an androgen-dependent organ. However, there is evidence that estrogens may induce mitosis of prostatic epithelial cells in many species, including humans (Leave et al., 1978; Schulze et al., 1987). This report analyzes the association between prostate cancer and estrogen metabolism investigated in a case-control study. In particular, we tested the hypothesis that the pathway favoring 2-hydroxylation over 16alpha-hydroxylation may be associated with a decrease in prostate cancer risk. This is the final report for the study. During the final year of activity, we completed determinations of the estrogen metabolites using gas-chromatography and carried out statistical analysis.


Descriptors :   *PROSTATE CANCER , *ESTROGENS , *METABOLISM , PROSTATE GLAND , EUROPEAN UNION , ITALY , UNITED STATES , STATISTICAL ANALYSIS


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE