Accession Number : ADA487029


Title :   Endogenous 6-Hydroxymelatonin Excretion and Subsequent Risk of Breast Cancer: A Prospective Study


Descriptive Note : Final rept. 1 Mar 2004-29 Feb 2008


Corporate Author : ITALIAN NATIONAL CANCER INST REGINA ELENA ROME (ITALY)


Personal Author(s) : Muti, Paola C.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA487029


Report Date : MAR 2008


Pagination or Media Count : 45


Abstract : The prevalence of breast cancer is greatest in industrialized regions and exposure to light at night has been proposed as a potential risk factor. Modulation of melatonin secretion by light has been implicated in the causal pathway linking exposure to light and breast cancer risk. Recent evidence indicates that melatonin is a natural oncostatic agent capable of functioning through a variety of anti-proliferative, anti-oxidative, and immunostimulatory mechanisms. We conducted a study to investigate the association of prediagnostic melatonin production and subsequent breast cancer risk in a prospective cohort study, the Italian ORDET study. Thus, prediagnostic melatonin production was measured as urine levels of the 6-hydroxymelatonin sulphate (6-OHMS), its primary enzymatic metabolite, in 12-hour urine (overnight) collection. The study was conducted as a nested case-control study. We included XXX breast cancer cases among cohort members during the 17 year-follow-up period. Four controls were matched to each case on age, menopausal status, recruitment center and time of recruitment.


Descriptors :   *MELATONIN , *EXCRETION , *EXPOSURE(PHYSIOLOGY) , *BREAST CANCER , CASE STUDIES , METABOLITES , URINE , SECRETION , REGIONS , RECRUITING , PRODUCTION , RISK , MODULATION


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE