Accession Number : ADA486241
Title : Treatment of Prostate Cancer with a DBP-MAF-Vitamin D Complex to Target Angiogenesis and Tumorigenesis
Descriptive Note : Final rept. 1 Feb 2004-31 Jan 2008
Corporate Author : KENTUCKY UNIV LEXINGTON
Personal Author(s) : Fannon, Michael W.
Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA486241
Report Date : FEB 2008
Pagination or Media Count : 20
Abstract : The purpose of this study has been to determine the efficacy of combined therapy using vitamin D binding protein-macrophage activating factor (DBP-maf) and vitamin D as therapy for human prostate cancer. We had found that in endothelial tube formation vitamin D and DBP-maf inhibited the tube formation. Both molecules were effective on their own however the vitamin D showed evidence of toxicity at higher concentration. We here show that the combination of vitamin D, at a level ineffective by itself(10 pM), and DBP-maf at concentrations as low as 100 ng/ml show potent synergistic behavior. We observed that DBP-maf inhibits the expression of urokinase-type plasminogen activator receptor (UPAR), a molecule whose expression has been linked with increased metastasis. We also observed reduced expression of p21 and p27 by DBP-maf but not by the control DBP. The expression of UPAR by DBP-maf may explain its potent activity on tumors.
Descriptors : *PROSTATE CANCER , *PROTEINS , *ANGIOGENESIS , *VITAMIN D , PROSTATE GLAND , PHOSPHORUS TRANSFERASES , METASTASIS , THERAPY , TOXICITY , MOLECULES , HUMANS , SYNERGISM
Subject Categories : BIOCHEMISRTY
MEDICINE AND MEDICAL RESEARCH
Distribution Statement : APPROVED FOR PUBLIC RELEASE