Accession Number : ADA485951


Title :   Study of the Antitoxic Effect of Unithiol on Cystamine in Dogs


Descriptive Note : Technical rept. Jan-Jun 2008


Corporate Author : ITT CORP ALEXANDRIA VA ADVANCED ENGINEERING AND SCIENCE DIV


Personal Author(s) : Grachev, S. A. ; Sverdlov, A. G.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA485951


Report Date : AUG 2008


Pagination or Media Count : 39


Abstract : It was shown in experiments using a canine model that intramuscular administration of unithiol (monohydrate sodium salt of 2,3-dimercapto-1-propansulfonic acid, 50 mg/kg) before cystamine (cystamine dihydrochloride, 100 mg/kg, calculation on the salt, intragastric administration) decreases the toxic effect of this radioprotector. The frequency of manifestations of the toxic effects of cystamine (change of behavior, vomiting reaction, decrease of body temperature and so on) is not decreased, but the severity of expression and duration are decreased. The period of agitation induced by cystamine is shortened, and the period and expression of vomiting induced by this preparation are decreased. Respiratory frequency and condition of the heart are less changed (according to EKG data).


Descriptors :   *TOXICITY, *REDUCTION, *RADIOPROTECTIVE AGENTS, CHELATING AGENTS, DOGS


Subject Categories : http://www.w3.org/XML/1998/namespace
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Distribution Statement : APPROVED FOR PUBLIC RELEASE