Accession Number : ADA484690


Title :   A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer Risk


Descriptive Note : Annual rept. 1 Nov 2006-31 Oct 2007


Corporate Author : FOX CHASE CANCER CENTER PHILADELPHIA PA


Personal Author(s) : Xu, Xiangxi


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA484690


Report Date : NOV 2007


Pagination or Media Count : 34


Abstract : This project is to use a unique mouse model to study the interaction of reproductive factors and genetic mutations in the development of ovarian cancer. Ovarian cancer often develops in women of peri-menopausal age. We found that the germ cell deficient Wv mice mimics postmenopausal biology and develop benign ovarian tumors. We plan to test the hypothesis that a synergy exists between oncogenic mutations such as p53, pten, or p27kip1 and postmenopausal biology in ovarian cancer development. In the first year of the project, we completed Aim 1, the study of ovarian tumor phenotypes in mice of compound genotypes. We found that crossing of Wv mice into mutant p53, pten, or p27 background did not lead to a malignant tumor phenotype. Instead, the mutants rescue ovarian germ cells, a very interesting finding. The ovarian surface epithelia in these compound mutant mice develop unique lesions with peculiar morphology, which are undergoing analysis as planned in Aim 2. In future study, we plan to use flox-p53 mutant mice to create mutation only in ovarian surface epithelial but not in germ cells (Aim 3). In sum, the project progresses as planned. We have layered the basis and are posed to further advance.


Descriptors :   *OVARIAN CANCER , *ETIOLOGY , RISK , NEOPLASMS , MUTATIONS , GENETICS , ANATOMICAL MODELS , REPRODUCTION(PHYSIOLOGY) , GERM CELLS , ONCOGENIC VIRUSES , OVARIES , EPITHELIUM , TEST AND EVALUATION , MICE


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE