Accession Number : ADA478660


Title :   Deregulated Wnt Signaling in Prostate Cancer


Descriptive Note : Annual summary rept. 1 Jan-31 Dec 2007


Corporate Author : FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA


Personal Author(s) : Houghtaling, Scott


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA478660


Report Date : JAN 2008


Pagination or Media Count : 6


Abstract : The PCRP Prostate Cancer Training Award has supported my training for the past 12 months. During this time, I have continued to work towards attaining a better understanding of (a) the biology of prostate cancer, (b) the biology of the Wnt/beta-catenin signaling pathway, (c) the principle and application of cutting edge techniques in modern molecular and cellular biology, and (d) the principle and application of genetically engineered mouse (GEM) models, with the intent of becoming uniquely positioned to investigate the role of Wnt/beta-catenin signaling in the initiation, progression and metastasis of spontaneous autochthonous prostate cancer and the emergence of the androgen depletion independent phenotype. In addition to this rigorous technical training, I have continued to attend weekly lab meetings, division wide Cancer Biology Seminar series, and the Pacific Northwest SPORE in Prostate Cancer meetings. In addition, I attended the PCRP's Innovative Minds in Prostate Cancer Today (IMPaCT) meeting in Atlanta, Georgia.


Descriptors :   *PROTEINS , *PROSTATE CANCER , MOLECULAR BIOLOGY , MICE , METASTASIS


Subject Categories : GENETIC ENGINEERING AND MOLECULAR BIOLOGY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE