Accession Number : ADA476747
Title : Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer
Descriptive Note : Final rept. 1 Sep 2004-31 Aug 2007
Corporate Author : CALIFORNIA UNIV DAVIS
Personal Author(s) : Evans, Christopher P.
Report Date : SEP 2007
Pagination or Media Count : 61
Abstract : We have made headway into understanding the paracrine relationship between neuropeptide expressing, androgen-insensitive CaP cells and their ability to support the proliferation and migration of androgen sensitive CaP cells. Critically, we have identified src kinase as a molecule central to the process. We have been awarded a NIH CTEP phase II trial to study a novel, oral src kinase inhibitor AZD0530 in androgen-insensitive prostate cancer patients based upon our work.
Descriptors : *PEPTIDES , *GROWTH(PHYSIOLOGY) , *PROSTATE CANCER , SKILLS , NERVE CELLS , TESTES , ANDROGENS , EXCISION , PATIENTS , MOLECULES
Subject Categories : BIOCHEMISRTY
MEDICINE AND MEDICAL RESEARCH
Distribution Statement : APPROVED FOR PUBLIC RELEASE