Accession Number : ADA476747


Title :   Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer


Descriptive Note : Final rept. 1 Sep 2004-31 Aug 2007


Corporate Author : CALIFORNIA UNIV DAVIS


Personal Author(s) : Evans, Christopher P.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA476747


Report Date : SEP 2007


Pagination or Media Count : 61


Abstract : We have made headway into understanding the paracrine relationship between neuropeptide expressing, androgen-insensitive CaP cells and their ability to support the proliferation and migration of androgen sensitive CaP cells. Critically, we have identified src kinase as a molecule central to the process. We have been awarded a NIH CTEP phase II trial to study a novel, oral src kinase inhibitor AZD0530 in androgen-insensitive prostate cancer patients based upon our work.


Descriptors :   *PEPTIDES , *GROWTH(PHYSIOLOGY) , *PROSTATE CANCER , SKILLS , NERVE CELLS , TESTES , ANDROGENS , EXCISION , PATIENTS , MOLECULES


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE