Accession Number : ADA475262


Title :   Alanine Dosimetry Accurately Determines Radiation Dose in Nonhuman Primates


Descriptive Note : Special publication


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Nagy, V. ; Parra, N. C. ; Shoemaker, M. O. ; Elliott, T. B. ; Ledney, G. D.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA475262


Report Date : OCT 2007


Pagination or Media Count : 32


Abstract : The unique capabilities of the Armed Forces Radiobiology Research Institute's (AFRRI) cobalt-60 (Co60) gamma-photon irradiator were used for bilateral whole-body irradiation of the nonhuman primate (NHP) Macaca mulatta. In this study, 6.5 Gy radiation was delivered at 0.4 Gy/min to 24 male NHPs 7-10 years of age weighing 7-14 kg in order to evaluate the (a) pharmacokinetics and pharmacodynamics (PK/PD) of ciprofloxacin (CIP) in an irradiated non-rodent large-animal species phylogenetically close to man, (b) utility of CIP in managing postirradiation infection related to bacterial translocation from the alimentary canal, and (c) the side effects of CIP in acutely irradiated NHPs. This dose was chosen from published and unpublished studies indicating 6.5 Gy (a) approximated the LD50/30 for NHPs and (b) resulted in severe hematopoietic system injury with increased risk for death from sepsis. For irradiation, an acrylic plastic container was constructed to comfortably restrain large NHPs that were 60-80 cm in length. Three acrylic plastic cylinders (7, 10.1, and 12.6 cm in diameter) were used in conjunction with alanine pellets to estimate the dose to the mid-abdominal target area of various sized NHPs.


Descriptors :   *IONIZING RADIATION, *RHESUS MONKEYS, *DOSIMETRY, *ALANINES, *WHOLE BODY IRRADIATION, ESTIMATES, CONTAINERS, SEPSIS, COBALT, ANTIBIOTICS, PHARMACOKINETICS


Subject Categories : RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE