Accession Number : ADA472048
Title : Enhancing the Immune Response to Recombinant Plague Antigens
Descriptive Note : Final rept. 20 Sep 2002-31 Mar 2007
Corporate Author : TULANE UNIV NEW ORLEANS LA
Personal Author(s) : Clements, John D.
Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA472048
Report Date : MAY 2007
Pagination or Media Count : 24
Abstract : The etiologic agent of plague is the Gram negative bacterium Yersinia pestis. Y. pestis is a concern as one of the microorganisms with potential for use against civilian or military populations as a biological warfare/ biological terrorism agent. In that case, the pneumonic form of plague would be the most likely outcome. This form of plague is particularly devastating because of the rapidity of onset, the high mortality, and the rapid spread of the disease. Immunization against aerosolized plague presents a particular challenge for vaccine developers. The studies reported herein explore the ability of a novel adjuvant, designated LT(R192G), to promote the rapid development of long-lasting, high titer antibodies against a recombinant plague antigen (F1-V) and protection in a murine model. Subsequent studies will be performed in non-human primates. Different routes of administration are examined to test the hypothesis that heterologous boosting will be more effective than homologous boosting at increasing the magnitude and/or duration of the antibody response.
Descriptors : *ANTIBODIES , *YERSINIA PESTIS , ANTHRAX , BIOLOGICAL WARFARE AGENTS , MORTALITY RATE , ANTIGENS , IMMUNIZATION , VACCINES , MICROORGANISMS , PLAGUES
Subject Categories : MEDICINE AND MEDICAL RESEARCH
Distribution Statement : APPROVED FOR PUBLIC RELEASE