Accession Number : ADA470814


Title :   Topical Application of Liposomal Antioxidants for Protection Against CEES Induced Skin Damage


Descriptive Note : Annual rept. 1 Jul 2006-30 Jun 2007


Corporate Author : EAST TENNESSEE STATE UNIV JOHNSON CITY


Personal Author(s) : Stone, William L. ; Paromov, Victor ; Yang, Hongsong


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA470814


Report Date : JUL 2007


Pagination or Media Count : 33


Abstract : The objective of this study is to develop an effective prophylactic therapy against an analog of mustard gas, 2-chloroethylethyl sulfide (CEES). The therapy for CEES-induced skin damage will be based on the topical application of antioxidant liposomes. We will use EpiDerm cultured human skin tissues as well as cultured keratinocytes as working models. HD/CEES-induced pathophysiology involves oxidative stress. Liposomes, containing both water- and lipid-soluble antioxidants, are expected to be an effective antidote/therapeutic product to protect US military and civilians from a chemical warfare agent such as HD. The therapeutic efficacy, as well as the chemical and physical stability of various antioxidant liposome formulations, will be examined to determine the optimal preparation for future testing in animal models.


Descriptors :   *LIPOSOMES , *SKIN(ANATOMY) , *ANTIOXIDANTS , *HD AGENT , TOXICITY , VITAMIN E , CHEMICAL WARFARE INJURIES , PROTECTION , ANTIDOTES , THERAPY


Subject Categories : TOXICOLOGY
      CHEMICAL, BIOLOGICAL AND RADIOLOGICAL WARFARE


Distribution Statement : APPROVED FOR PUBLIC RELEASE