Accession Number : ADA469216
Title : A Method for the Analysis of Tabun in Multisol Using Gas Chromatographic Flame Photometric Detection
Descriptive Note : Technical rept.
Corporate Author : ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
Personal Author(s) : Logan, Thomas P ; Allen, Edward D ; Way, Mark R ; Swift, Austin T ; Soni, Sunil-Datta
Report Date : May 2006
Pagination or Media Count : 15
Abstract : In the past we have found tabun (GA) in saline at 2 microgram/ml to be stable for only a month or less at -70 degrees C. Previous studies have shown that Multisol provides stable solutions of GA. We confirmed the stability of GA in Multisol with phosphorus nuclear magnetic resonance and developed a method for the analysis of GA in Multisol using gas chromatographic flame photometric detection (GCFPD) in the phosphorus mode. The GC method used acetonitrile (CH3CN) for a dilution solvent because of its miscibility with GA in chloroform (CHC13) standards and GA in Multisol samples at 1% (v/v). Furthermore, the dilutions with CH3CN made the phosphorus mode interference peak present in CHC13 analytically manageable, reduced the interferences of Multisol in the GC separation, and contributed to a safe and reliable analysis of GA at 20 microgram/ml. We demonstrated the stability of GA in Multisol stored for more than a year at -70 degrees C. This method contributes a suitable technique for the preparation and analysis of reliable solutions of GA in nerve agent medical research and demonstrates the extended stability of GA in Multisol.
Descriptors : *GAS CHROMATOGRAPHY , *GA AGENT , NUCLEAR MAGNETIC RESONANCE , PHOTOMETRY , CHLOROFORM , DETECTORS , NERVE AGENTS
Subject Categories : Physical Chemistry
Chemical, Biological and Radiological Warfare
Distribution Statement : APPROVED FOR PUBLIC RELEASE