Accession Number : ADA467982


Title :   Hepatocyte Growth Factor and Interleukin-6 in Prostate Cancer Bone Metastasis


Descriptive Note : Final rept. 15 Feb 2002-14 May 2006


Corporate Author : FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA


Personal Author(s) : Knudsen, Beatrice S.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA467982


Report Date : JUN 2006


Pagination or Media Count : 51


Abstract : The hypothesis of this grant proposal is that androgen-ablative therapy paradoxically increases growth factor secretion from bone stromal cells and that this may stimulate the growth of prostate cancer metastases. Based on the presence of androgen receptor regulatory elements in the promoter regions of the Interleukin-6 (IL-6) and hepatocyte growth factor/scatter factor (HGF/SF) genes and the presence of nuclear factor IL-6 binding sites in the promoter of the HGF gene, it is the premise of this project that IL-6 and HGF genes may serve as paradigms of genes that are increased in expression under androgensuppressed conditions. However, initial experiments failed to reveal regulation of HGF and IL-6 by androgen suppression. An analysis of global gene regulation in castrated mice demonstrated that 159 genes were regulated and that Insulin growth Factor Binding Protein-5 demonstrated the most consistent increase in expression. The support provided by the grant fostered the PI's career development to an independent investigator in the field of prostate cancer metastasis to bone. There were several publications supported by the funds from this grant.


Descriptors :   *BONES , *METASTASIS , *PROSTATE CANCER , GENES , CELLS(BIOLOGY) , ANDROGENS , GROWTH(PHYSIOLOGY) , EXCISION


Subject Categories : ANATOMY AND PHYSIOLOGY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE