Accession Number : ADA462917


Title :   Targeting Stromal Recruitment by Prostate Cancer Cells


Descriptive Note : Annual summary rept. 15 Feb 2004-14 Feb 2006


Corporate Author : WISCONSIN UNIV-MADISON


Personal Author(s) : Zhang, Jingxian


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a462917.pdf


Report Date : Mar 2006


Pagination or Media Count : 54


Abstract : Sonic hedgehog(shh)overexpression in LNCaP cells accelerates tumor growth. To characterize the contributions of each Gli gene to Shh-induced tumor growth, Gli1, Gli2 and Gli3 knockout UGSM cells have been isolated and UGSM-2 cells independently over-expressing hGli1 and hGli2 were cloned. Experiments using those cell lines co-injected with LNCaP cells in the Xenograft model indicate stromal Shh signaling activation may play an important role in the tumor growth.


Descriptors :   *RIBONUCLEIC ACIDS , *ADENOVIRUSES , *PROSTATE CANCER , ACTIVATION , GENES , SURGICAL TRANSPLANTATION , PROSTATE GLAND , CLONES , CELLS(BIOLOGY)


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE