Accession Number : ADA462388


Title :   IGF-Regulated Genes in Prostate Cancer


Descriptive Note : Final rept. 1 Feb 2002-31 Jan 2006


Corporate Author : OREGON HEALTH AND SCIENCES UNIV PORTLAND


Personal Author(s) : Roberts, Jr, Charles T


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a462388.pdf


Report Date : Feb 2006


Pagination or Media Count : 40


Abstract : In this project, we have analyzed the role of the IGF signaling system in prostate cancer initiation and progression. Our original hypothesis stated that, since the IGF system is an important factor in tumorigenesis and prostate cancer, that genes and proteins that were differentially expressed in cells that expressed different levels of the IGF-I receptor that mediates the intracellular effects of the IGFs may themselves constitute potential diagnostic factors or therapeutic targets. During the period of this award, we have analyzed differential gene expression and protein secretion in genetically engineered metastatic and nonmetastatic prostate cancer cells expressing different levels of the IGF-IR. These studies were in direct support of the original statement of work. In addition, we have: 1) defined the transcriptional regulation of the IGF-I gene; 2) reported the regulation of IGF signaling by saw palmetto; 3) described the interaction between the IGF-IR and the androgen receptor; 4) identified a novel product of the Her2 gene that regulates IGF action; and 5) reviewed the role of IGF action in prostate cancer. These findings are represented by the peer-reviewed publications summarized in this final report and provided as appendices.


Descriptors :   *HYPOTHESES , *PROSTATE CANCER , *ANDROGENS , *CELLS(BIOLOGY) , *GENES , *DIAGNOSIS(MEDICINE) , THERAPY , SURFACE ACOUSTIC WAVES , TRANSCRIPTION(GENETICS) , METASTASIS , REGULATIONS , PRODUCTION , SIGNALS , SECRETION , TARGETS , NEOPLASMS , PROTEINS , SENSE ORGANS


Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE